Is Hepatitis Delta infections important in Brazil?

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Is Hepatitis Delta infections important in Brazil?

BACKGROUND The Hepatitis Delta Virus (HDV) can increase the incidence of fulminant hepatitis. For this infection occurs, the host must also be infected with Hepatitis B Virus. Previous studies demonstrated the endemicity and near exclusivity of this infection in the Amazon region, and as a consequence of the difficulty in accessing this area we used dried blood spots (DBS) in sample collection....

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Large hepatitis delta antigen is not a suppressor of hepatitis delta virus RNA synthesis once RNA replication is established.

Moderation of hepatitis delta virus (HDV) replication is a likely prerequisite in the establishment of chronic infections and is thought to be mediated by the intracellular accumulation of large hepatitis delta antigen (L-HDAg). The regulatory role of this protein was suggested from several studies showing that cotransfection of plasmid cDNAs expressing both L-HDAg and HDV RNA results in a pote...

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Hepatitis delta virus RNA editing is highly specific for the amber/W site and is suppressed by hepatitis delta antigen.

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Delta hepatitis: an update.

Hepatitis delta virus (HDV) is a unique defective RNA virus that requires the helper function of hepatitis B virus (HBV), which provides the essential coat protein for virion assembly and propagation. It is the smallest animal virus and the only one to possess a circular RNA genome, as seen in plant viruses. HDV has evolved into three major genotypes that differ in their geographic distribution...

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ژورنال

عنوان ژورنال: BMC Infectious Diseases

سال: 2016

ISSN: 1471-2334

DOI: 10.1186/s12879-016-1856-9